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er stress inhibitor 4 pba  (MedChemExpress)


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    MedChemExpress er stress inhibitor 4 pba
    Er Stress Inhibitor 4 Pba, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 317 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/er+stress+inhibitor+4+pba/4-Phenylbutyric+acid/pm41862947-59-5-12
    Average 97 stars, based on 317 article reviews
    er stress inhibitor 4 pba - by Bioz Stars, 2026-09
    97/100 stars

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    Related Articles

    Activation Assay:

    Article Title: Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway.
    Article Snippet: To confirm whether ROS was involved in the regulatory effect of PRC1 on ER stress, CRC cells were pretreated with the ROS scavenger N-acetylcysteine (NAC; 2 mM, MCE, Shanghai, China) for 2 h prior to gene transfection to block ROS generation. .. To determine the involvement of ER stress in PRC1-mediated ICD, CRC cells were treated with the ER stress inhibitor 4-PBA (4 mM, MCE) for 48 h. For activation of the Wnt/β-catenin signaling pathway, CRC cells were treated with a Wnt activator BML-284 (0.5 μM, MCE) for 48 h. .. Small interfering RNA (siRNA) targeting PRC1 (si-PRC1) and its negative control (si-con) was designed and synthesized by Guangzhou Ribobio (China).

    Article Title: Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/ β -catenin signaling pathway
    Article Snippet: To confirm whether ROS was involved in the regulatory effect of PRC1 on ER stress, CRC cells were pretreated with the ROS scavenger N-acetylcysteine (NAC; 2 mM, MCE, Shanghai, China) for 2 h prior to gene transfection to block ROS generation. .. To determine the involvement of ER stress in PRC1-mediated ICD, CRC cells were treated with the ER stress inhibitor 4-PBA (4 mM, MCE) for 48 h. For activation of the Wnt/ β -catenin signaling pathway, CRC cells were treated with a Wnt activator BML-284 (0.5 μM, MCE) for 48 h. .. Small interfering RNA (siRNA) targeting PRC1 (si-PRC1) and its negative control (si-con) was designed and synthesized by Guangzhou Ribobio (China).

    Control:

    Article Title: USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells.
    Article Snippet: .. For the signal pathway regulation experiment, Huh7 cells were treated with the ER stress inhibitor 4-PBA (MedChemExpress, Monmouth Junction, NJ, USA), the ER stress agonist TM (Macklin Biotech Co., Ltd., Shanghai, China), the PERK agonist CCT020312 (MedChemExpress) or the vehicle control dimethyl sulfoxide (DMSO) for 24 h, respectively. ..

    Article Title: USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2α-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells
    Article Snippet: .. For the signal pathway regulation experiment, Huh7 cells were treated with the ER stress inhibitor 4-PBA (MedChemExpress, Monmouth Junction, NJ, USA), the ER stress agonist TM (Macklin Biotech Co., Ltd., Shanghai, China), the PERK agonist CCT020312 (MedChemExpress) or the vehicle control dimethyl sulfoxide (DMSO) for 24 h, respectively. ..



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    endoplasmic reticulum stress ers inhibitor 4 pba  (MedChemExpress)
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    Inhibition of ER stress <t>with</t> <t>4-PBA</t> can significantly improve liver injury caused by ischemia-reperfusion in mice. (A) The relative mRNA levels of GRP78 and CHOP genes in the sham, 4-PBA (20 mg/kg), HIRI-6h, and HIRI-6h+4-PBA (20 mg/kg) groups. (B) The serum ALT and AST levels were detected in each group. (C) The histopathological features of the liver were observed in each group by H&E staining. Black arrows indicated the area of liver cell necrosis. (D) The cell apoptosis of liver tissues in each group were detected by TUNEL staining. The white arrow marks the area where apoptotic cells are located. (E) The mRNA expression levels of liver injury-related genes were measured by qRT-PCRs in each group. (F) The mRNA expression levels of liver inflammation-related genes were analyzed by qRT-PCRs in each group. The results were obtained from at least three independent experiments. Values are presented as mean ± SEM. ** p < 0.05, ** p < 0.01 vs. the HIRI-6h group.
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    Inhibition of ER stress with 4-PBA can significantly improve liver injury caused by ischemia-reperfusion in mice. (A) The relative mRNA levels of GRP78 and CHOP genes in the sham, 4-PBA (20 mg/kg), HIRI-6h, and HIRI-6h+4-PBA (20 mg/kg) groups. (B) The serum ALT and AST levels were detected in each group. (C) The histopathological features of the liver were observed in each group by H&E staining. Black arrows indicated the area of liver cell necrosis. (D) The cell apoptosis of liver tissues in each group were detected by TUNEL staining. The white arrow marks the area where apoptotic cells are located. (E) The mRNA expression levels of liver injury-related genes were measured by qRT-PCRs in each group. (F) The mRNA expression levels of liver inflammation-related genes were analyzed by qRT-PCRs in each group. The results were obtained from at least three independent experiments. Values are presented as mean ± SEM. ** p < 0.05, ** p < 0.01 vs. the HIRI-6h group.

    Journal: Frontiers in Pharmacology

    Article Title: Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice

    doi: 10.3389/fphar.2025.1519497

    Figure Lengend Snippet: Inhibition of ER stress with 4-PBA can significantly improve liver injury caused by ischemia-reperfusion in mice. (A) The relative mRNA levels of GRP78 and CHOP genes in the sham, 4-PBA (20 mg/kg), HIRI-6h, and HIRI-6h+4-PBA (20 mg/kg) groups. (B) The serum ALT and AST levels were detected in each group. (C) The histopathological features of the liver were observed in each group by H&E staining. Black arrows indicated the area of liver cell necrosis. (D) The cell apoptosis of liver tissues in each group were detected by TUNEL staining. The white arrow marks the area where apoptotic cells are located. (E) The mRNA expression levels of liver injury-related genes were measured by qRT-PCRs in each group. (F) The mRNA expression levels of liver inflammation-related genes were analyzed by qRT-PCRs in each group. The results were obtained from at least three independent experiments. Values are presented as mean ± SEM. ** p < 0.05, ** p < 0.01 vs. the HIRI-6h group.

    Article Snippet: Endoplasmic reticulum stress (ERS) inhibitor 4-PBA (Cas no. HY-A0281) was purchased from MedChemExpress Co., Ltd. (MCE, United States).

    Techniques: Inhibition, Staining, TUNEL Assay, Expressing